أولاً: التوعية الدوائية:
| Content | Issue date | Issue |
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• Infliximab- Use of Live Vaccines in Infants Exposed in Utero or During Breastfeeding •Local Case Report: Cefotaxime - Anaphylactic shock, Hypersensitivity, Hypoxia and Rash |
08/2022 | |
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•Citalopram & Escitalopram - Risk of Dosedependent Qt interval prolongation 1 •Local Case Report: Isotretinoin - Case of Skin rash, dryness and Blurred vision 2 |
07/2022 | |
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• Injectable Trime-butine- Risk of Cardiac Tox-icity in the Event of Misuse •Local Case Report: Pheno-barbital - Case of Apnea |
06/2022 | |
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• Alert: Xoraxone Vial Counterfeit 1 • Bone marrow suppression with methotrexate and trimethoprim or trimethoprim with sulfamethoxazole 2 • Local Case Report: Ceftriaxone with ketorolac - Anaphylactic shock 3 |
05/2022 |
(148) Newsletter-Hundred forty-eight May 2022
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11/2021 | |
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10/2021 | (141) Newsletter-Hundred Forty One October 2021 |
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09/2021 | (140) Newsletter-Hundred Forty September 2021 |
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08/2021 | (139) Newsletter-Hundred Thirty-nine August 2021 |
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07/2021 | |
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06/2021 | |
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01/2021 |
ثانياً: خطابات موجهة لمقدمى الخدمات الصحية:
| Content | Issue date | Issue |
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Increased risk of Cardiovascular Events & Cardiovascular Mortality when Hydroxychloroquine or Chloroquine used with Macrolide antibiotics |
4/2022 | |
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PAXLOVID Emergency Use Authorization (EUA) dosing and dispensing in moderate |
3/2022 | |
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Anagrelide hydrochloride: Risk of thrombosis including cerebral infarction upon abrupt treatment discontinuation |
3/2022 | |
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Mavenclad (Cladribine) – risk of serious liver injury and new recommendations about liver function monitoring |
3/2022 | |
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Infliximab: Use of live vaccines in infants exposed in utero or during breastfeeding |
3/2022 | |
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Levocetirizine shouldn’t be used in children less than 2 years |
2/2022 | |
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Important Safety Information Regarding Use of Molnupiravir in Pregnancy and Individuals of Childbearing Potential |
2/2022 | |
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Octreotide Solution for Subcutaneous injection and intravenous infusion: Risk of atrioventricular block |
2/2022 | |
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Olsalazine – Severe cutaneous adverse reactions, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP) |
2/2022 | |
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Donepezil-QTc interval extension and Torsade de Pointes |
1/2022 | |
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Glatiramer Acetate: Rare cases of severe liver damage |
1/2022 | |
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Amiodarone Hydrochloride 50 mg/ml concentrate for solution for |
1/2022 | DHPC Amiodarone |
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Dapagliflozin 5mg should no longer be used for the treatment of Type 1 Diabetes Mellitus |
1/2022 | DHPC Dapagliflozin |
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Dinoprostone: Add A Restriction On Use And Update Of Dosage Recommendations, Warnings And Especially Adding Recommendations On The Risks Of Hyperstimulation Uterine, Uterine Rupture And Fetal / Neonatal Mortality |
1/2022 | |
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COVID-19 mRNA Vaccine Spikevax (previously Moderna): risk of myocarditis and pericarditis |
11/2021 | |
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COVID-19 mRNA Vaccine Comirnaty: risk of myocarditis and pericarditis |
11/2021 |
COVID-19 mRNA Vaccine Comirnaty: risk of myocarditis and pericarditi |
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COVID-19 Vaccine AstraZeneca: Risk of thrombocytopenia (including immune thrombocytopenia) with or without associated bleeding |
10/2021 | |
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COVID-19 Vaccine Janssen: Risk for immune thrombocytopenia (ITP) and venous thromboembolism (VTE) |
10/2021 | |
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COVID-19 Vaccine AstraZeneca: contraindication in individuals with previous capillary leak syndrome |
6/2021 | COVID-19 Vaccine AstraZeneca contraindication |
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It was noted that the dosing information (specifically the timing of dosing with respect to food) in the product information for the levodopa-containing products was not optimal: it did not make clear that dosing without food is possible, and maybe preferable for some patients. |
6/2021 | Updating Dosing Information Levodopa |
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COVID-19 Vaccine Janssen: Contraindication in individuals with previous capillary leak syndrome and update on thrombosis with thrombocytopenia syndrome Capillary leak syndrome (CLS) Thrombosis with thrombocytopenia syndrome(TTS) |
6/2021 |
J&J Covid 19 Vaccine |
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COVID-19 Vaccine AstraZeneca: Risk of thrombosis in combination with |
6/2021 | |
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Tofacitinib: initial clinical trial results of increased risk of major adverse cardiovascular events and malignancies (excluding NMSC) with use of tofacitinib relative to TNF-alpha inhibitors. |
4/2021 | |
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COVID-19 Vaccine AstraZeneca: Risk of coagulation disorders with or |
4/2021 | |
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As the leaflets available in the packs of Leflunomide tablets are currently undergoing important safety updates, we would like to inform you of these important safety updates till their implementation in packs. |
3/2021 | |
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The off-label use of trimebutine by injection is of concern with regard to its cardiac toxicity |
5/2022 | |
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Citalopram and Escitalopram – Reminder of Risk of Dose Dependent QT interval Prolongation |
7/2022 |