أولاً: التوعية الدوائية:
| Content | Issue date | Issue |
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- DHPC for Dimethyl Fumarate - Safety Communication for Emicizumab - Local Case Report: Cyclizine - EPVC News |
01/2021 | |
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- SSRI/SNRI risk of post-partum hemorrhage - Local Case Report: Sildenafil - EPVC News |
02/2021 | |
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- Erythromycin Cardiac Risk and Interaction with Rivaroxaban - Local Case Report: Furosemide - EPVC News |
03/2021 | |
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- Erythromycin: Update on Risk of Infantile Hypertrophic Pyloric Stenosis - Local Case Report: Ceftriaxone - EPVC News |
04/2021 | |
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- Bupropion: risk of serotonin syndrome - Local Case Report: Warfarin |
05/2021 | |
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- Polyethylene glycol (PEG) laxatives and starch-based thickeners: risk of aspiration - Local Case Report: Interaction between Warfarin and Naproxen - EPVC News |
06/2021 | |
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- Obeticholic acid: Restriction of use - Local Case Report: Fluorouracil - EPVC News |
07/2021 | |
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- Bendamustine: Risk of nonmelanoma skin cancer - Levodopa DHPC 2 - Local Case Report: Lamivudine and Sulipride |
08/2021 | (139) Newsletter-Hundred Thirty-nine August 2021 |
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- Colchicine: High risk of fatality with Colchicine over-dose - Fingolimod: Updated advice about the risks of serious liver injury and herpes meningoencephalitis - EPVC News |
09/2021 | (140) Newsletter-Hundred Forty September 2021 |
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- COVID-19 Vaccine Astra-Zeneca: Warning for Guillain-Barre syndrome - Topical corticosteroids: Information on the risk of topical steroid withdrawal reactions - EPVC News |
10/2021 | |
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- DHPC: COVID-19 mRNA Vaccine Comirnaty: Risk of Myocarditis and Pericarditis. - Local Case Report: A Case of Drug Abuse Resulted in Acute Renal Injury, Cardiomegaly, Muscle Weakness, Ulcers, Sepsis and Finally Death Following Paraffin Oil, Anabolic Steroids and Synthol Local Administration |
11/2021 |
ثانياً: خطابات موجهة لمقدمى الخدمات الصحية
| Content | Issue date | Issue |
| As the leaflets available in the packs of Leflunomide tablets are currently undergoing important safety updates, we would like to inform you of these important safety updates till their implementation in packs. | 03/2021 | Leflunomide Safety Updates |
| COVID-19 Vaccine AstraZeneca: benefits outweigh the risks despite possible link to very rare blood clots with low blood platelets. | 04/2021 | |
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Preliminary data from a completed clinical trial in rheumatoid arthritis patients (A3921133) suggest a higher risk of major adverse cardiovascular events (MACE) and malignancies (excluding non-melanoma skin cancer (NMSC)) with tofacitinib as compared to patients treated with a TNF-alpha inhibitor. |
04/2021 | Tofacitinib Updated safety information |
| COVID-19 Vaccine AstraZeneca: benefits outweigh the risks despite possible link to very rare blood clots with low blood platelets. | 06/2021 | |
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Capillary leak syndrome (CLS) Thrombosis with thrombocytopenia syndrome (TTS) |
06/2021 | J&J Covid 19 Vaccine Risk Of Capillary Leak Syndrome And TTS |
| It was noted that the dosing information (specifically the timing of dosing with respect to food) in the product information for the levodopa-containing products was not optimal: it did not make clear that dosing without food is possible, and maybe preferable for some patients. | 06/2021 | Updating Dosing Information Levodopa |
| COVID-19 Vaccine AstraZeneca: contraindication in individuals with previous capillary leak syndrome | 06/2021 | COVID-19 Vaccine AstraZeneca contraindication |
| COVID-19 Vaccine Janssen: Risk for immune thrombocytopenia (ITP) and venous thromboembolism (VTE) | 10/2021 | COVID-19 Vaccine Janssen Risk for immune thrombocytopenia |
| COVID-19 Vaccine AstraZeneca: Risk of thrombocytopenia (including immune thrombocytopenia) with or without associated bleeding | 10/2021 | COVID-19 Vaccine AstraZeneca Risk of thrombocytopenia |
| COVID-19 mRNA Vaccine Comirnaty: risk of myocarditis and pericarditis | 11/2021 | COVID-19 mRNA Vaccine Comirnaty: risk of myocarditis and pericarditi |
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COVID-19 mRNA Vaccine Spikevax (previously Moderna): risk of myocarditis and pericarditis
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11/2021 | DHPC for Moderna concerning pericarditis |